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Chrono™ Senso-MM

For the maturation of Sensory Neurons into electrophysiological responsive neurons by end users.

Chrono™ Senso-MM is the maturation medium for hiPSC-derived sensory neurons. Designed with the end user in mind, Chrono™ Senso-MM rapidly matures sensory neurons purchased as RealDRG™ or differentiated using Chrono™ Senso-DM.

The advanced nature of Anatomic's Chrono™ suite of products drastically cuts the production and maturation time of neurons from human pluripotent stem cells. Differentiation of human pluripotent stem cells into dorsal root ganglia-like sensory neurons is reduced to seven days from the traditional 35 days or more.

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Pharmaceutical companies, academic research facilities and other research labs are free to innovate and experiment with cutting-edge pain treatment and pain drug discovery. Applications for hiPSC-derived sensory neurons continue to grow as new application notes are developed.

Fast, Functional and Easy to Use

The entire Chrono™ series is designed with researchers of all skill levels in mind. Rapid maturation from nociceptors with Chrono™ Senso-MM only requires standard laboratory equipment and materials, and its ease of use makes it possible to successfully mature hiPSC-derived sensory neurons.

Maturing the Chrono™ Sensory Neurons requires no antimicrobial agents when standard aseptic techniques are used during plating. Maturation is straightforward, with a standard volume feeding every second day.

Proven Real-World Results

Within one week of maturation using Chrono™ Senso-MM,  ion channels, potassium, calcium and sodium currents are present and firing action potentials are verifiable via patch-clamp electrophysiology and microelectrode array studies. Electrophysiological studies can be performed in either current or voltage clamp modes.

Multi-electrode testing provides data for the firing pattern of both sensory neurons. This includes voltage-gated sodium Nav1.7, Nav1.8 and Nav1.9, calcium ion channels, and TrpV1. MEA studies displayed appropriate responses to both capsaicin and lidocaine.

The Highest Quality hiPSC-Derived Sensory Neuron Protocol

An Anatomic hiPSC-derived sensory neuron is Not Your Average Neuron™. We employ serum-free, chemically defined media formulations, eliminating the variability of undefined reagents and providing reliable and consistent results. Our matrices and growth factors drive de-novo differentiation of pure neuronal subpopulations.

With its seven-day process, Anatomic's protocol and Chrono™ hiPSC-derived sensory neuron culture media formulations provide researchers with more time for data interpretation, innovation and treatment possibilities.

To discuss how Senso-DM, RealDRG™ and Senso-MM can reduce experiment preparation time and improve testing speed in your facility, contact us today.

Chrono™ Senso-MM Resources

Senso-MM Product Manual

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