Anatomic rapidly generates Schwann cell precursors (SCP) from human induced pluripotent stem cells (hiPSCs) in just 9 days, offering a promising model for studying diseases like diabetic neuropathy and Charcot-Marie-Tooth syndrome. These SCPs, when co-cultured with our hiPSC-derived sensory and motor neurons, align within a week. Myelination markers are expressed as the SCPs are matured and further validated by transmission electron microscopy. Our model allows for screening with tool compounds and functional analysis using multi-electrode arrays, advancing the study of peripheral nervous system diseases.
Proven in a Number of Assays
We've performed extensive assay development for a number of techniques so that your first experiments will run smoothly. Without the need for extensive optimization, researchers can focus on discovery and innovation.
Alignment
Myelination
qPCR
Rapid Maturation
Optimized for Screening
MEA
Immunocytochemistry
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RealSCP Quick Guide
Version 1.2
Updated 04SEPT2024