Moto-DM

Human pluripotent stem cell differentiation kit for the rapid manufacture of motor neurons by end users.

Moto-DM is a human pluripotent stem cell differentiation (hiPSC) kit that allows researchers to rapidly manufacture motor neurons at the scale. Suitable for pharmaceutical companies and academic labs with their own wild-type and disease hiPSC lines, this differentiation media provides the ability for ALS, CMT, and neuromuscular disease modeling. Anatomic's breakthrough in producing ectoderm from hiPSCs within 24 hours provides near-immediate access to engineering neuron diversity unique to the nervous system. Moto-DM builds upon these findings to produce a highly pure population of immature motor neurons within only seven days.

PRODUCTS

Successful Production of hiPSC-Derived Motor Neurons

Moto-DM requires only standard laboratory equipment and is designed for use by researchers of all skill levels. The easy-to-complete production of human pluripotent stem cell-derived motor neurons is part of a complementary suite of motor neuron products for a variety of research interests.

Moto-MM: for the rapid maturation of ion channels and electrophysical activity
RealMOTO™: cryopreserved motor neurons for off-the-shelf use

Anatomic's Moto-DM was developed to put the power of your research back into your own hands. User-friendly, high-quality and researcher-focused, our human pluripotent stem cell differentiation kit allows your lab to consistently innovate, experiment and discover new pain treatments faster and more reliably than ever before.

Anatomic Produces a Highly Pure Population in Only 7 Days

By allowing neuroscience researchers to manufacture motor neurons, entire research teams can develop new workflows, streamline processes and focus on innovation and results.

Fast

Moto-DM produces differentiation of human pluripotent stem cells into motor neurons faster than ever, with a pure population of immature motor neurons in seven days.

Effective

Manufactures up to 10 million motor neurons with 75% purity for HB9, ISL1, TUJ1 and CHAT.

Quality Controlled

To eliminate variability, Moto-DM uses serum-free, chemically defined media and has been validated for use downstream from multiple defined systems for the undifferentiated culture of hiPSCs.

Anatomic Produces a Highly Pure Population in Only 7 Days

The Moto-DM Kit produces motor neurons from hiPSCs in just 7 days. Following ectoderm induction in 24 hours, cells are patterned into spinal ectoderm (HOXB1+, SOX2+) and motor progenitors (OLIG2+), reaching HB9+/ISL1+/TUJ1+ immature motor neurons by day 7. Moto-DM is ideal for modeling neuromuscular disorders such as ALS, SMA, or CMT, with efficient, reproducible outcomes.

Proven in a Number of Assays

We've performed extensive assay development for a number of techniques so that your first experiments will run smoothly. Without the need for extensive optimization, researchers can focus on discovery and innovation.